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Pharma and Biotech
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Pharma and Biotech
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Pharma and Biotech
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Pharma and Biotech
Pharma and Biotech
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Filling and packaging sterile liquids in vials and infusion bottles can be very demanding on system technology. We help you meet these challenges with individually designed, platform-based machine solutions – and, of course, constant communication.
Good to know: Optima offers perfectly integrated filling lines, isolators and freeze-dryers as turnkey solutions from a single source.
One thing we know for certain: You often encounter time and budget challenges with filling and packaging high-quality pharmaceuticals in vials and infusion bottles. With your input, we will design the ideal solution for your requirements. The time-to-market must be short and product losses minimal. We repeatedly demonstrate our expertise as a turnkey partner in system design with the successful implementation of complex vial systems, complete with isolators and freeze-dryers.
We utilize the Comprehensive Scientific Process Engineering (CSPE) approach to ensure your product gets to market quickly and safely. During operation, smart innovations minimize process and system downtime, as well as reducing product losses to a maximum of one object per batch. Digital components and services also guarantee uncompromising quality, maximum safety and optimal flexibility.
The first step is to clean your vials and infusion bottles in fully automated washing machines – available with optional ultrasonic pre-treatment. Single or multi-point grippers transport the products in either intermittent or continuous motion. Special designs can reduce your water consumption by up to 45%.
Benefits:
After the glass containers progress through the washer, they proceed to the sterilization tunnel where they are sterilized and depyrogenized. From cleaning and sterilization to sterile filling, all Optima systems are part of a complete aseptic filling line that provide a continuous process in cleanroom conditions.
Benefits:
Whether viscous or water-like liquids, we offer the appropriate filling solution for every product type and batch size. If the right solution isn't already available, we will work with you to develop it. Our experience with a wide range of applications, like biotech, biosimilar, generic medicines, vaccines, blood plasma or oncology give us unique knowledge to create a solution for your needs. Available filling technologies include rotary piston pumps, peristaltic pumps or time pressure filling systems. Additionally, other filling systems can also be integrated.
Benefits:
Our systems close your vials and infusion bottles fully automatically with all standard closures using state-of-the-art closing machines. These machines handle all standard closures for closed vials, ensuring a secure vial cap every time. We employ technology that minimizes product loss to maximize yield. Advanced techniques such as gassing during the closing process ensure a residual oxygen content of less than one percent, which is crucial when filling highly sensitive products.
Benefits:
The fifth step, if required by the product, is lyophilization or freeze-drying, extending the shelf life of the ingredients. As a turnkey provider, we connect this step seamlessly to the filling line – for optimal efficiency in your production process. Our freeze-dryers are scalable for every production quantity, from small clinical batches to large commercial batches. We also offer loading and unloading systems tailored to your freeze-drying requirements - from manual to fully automatic systems.
At the end of the process chain, the system collects the objects in a magazine. The injection and infusion bottles are magazined by the system in the exact quantities and hexagonally offset. The magazining system can fill two or four magazines alternately. This means that magazine changes take place without stopping the machine.
Benefits:
Containment solutions such as isolators supplement our turnkey portfolio for vial and bottle filling. The isolators can be combined with any type of pharmaceutical system.
Whether start-up or large corporation: We partner with biotech and pharmaceutical companies all over the world - designing systems for filling products in clinical studies, as well as small, medium and large commercial production batches. With our holistic understanding, experience and ingenuity, we find solutions for highly available, flexible and process-safe handling of your products. Turnkey systems from Optima Pharma fill blood plasma products, cell and gene therapy products, vaccines, high potency products, biosimilar, generic pharmaceuticals, biotech and veterinary medical products.
Because every drop counts: Rely on Optima’s smart solutions for filling blood plasma products – safety and productivity combined.
Highly sensitive cell and gene therapy products require flexible and automatable solutions for safe production and filling.
Time is often a critical factor in vaccine filling processes. Optima speeds up the filling and packaging of sterile liquids with innovative systems.
A complete overview is essential when filling and processing high potency pharmaceuticals – which is why we create comprehensive processes for maximum safety.
For challenging production requirements, we offer holistic process knowledge for aseptic filling, including maximum product protection.
Biopharmaceuticals are often expensive to obtain and produce. Therefore, we analyzed and restructured the entire filling and packaging process.
Whether re-dosing, re-stoppering and re-capping or 100% process control: A wide range of functions intertwine with one clear goal – maximum product yield and cost efficiency for you.
Biopharmaceuticals are often expensive to obtain and produce. Therefore, we analyzed and restructured the entire filling and packaging process.
Whether re-dosing, re-stoppering and re-capping or 100% process control: A wide range of functions intertwine with one clear goal – maximum product yield and cost efficiency for you.
For companies that manufacture and fill products essential to life, production safety processes are a top priority. This is why Optima systems feature sensors and cameras to monitor production. We offer a wide range of inspection and monitoring technology to safeguard your product quality in every aspect.
Digital solutions from Optima provide an overview of your production at all times so you can identify potential for improvement, increase availability of the system and receive direct support when needed. Optima developed the Intelligent Production Assistance Services (IPAS) to support you before and throughout the entire production process.
We work with you to determine the ideal solution for your aseptic filling application – from semi-automatic systems for small batch sizes in R&D or clinical studies, to a high-performance system with up to 45,000 units per hour and filling capacity of 500 milliliters.
We offer a complete machine portfolio for bulk vial processing:
